A truly genome-based classification and identification of your prokaryotic strains without overestimating phylogenetic confidence. Besides the phylogenomic approach, TYGS provides digital DNA:DNA hybrization values, differences in G+C content and more.
In microbial taxonomy a type strain is the nomenclatural type of a species. Whether or not a novel strain belongs to a particular species is thus determined by comparison to type strains. The comprehensive TYGS database contains a comprehensive collection of currently 10427 microbial type-strain genomes.
The TYGS web service implements many established methods (GGDC, GBDP) from recent years and provides fast data analysis on an entirely new level.
Submit your TYGS job and easily integrate the results into your study, thus significantly speeding-up your work. The TYGS pipeline covers many aspects of relevance to modern microbial taxonomy, including extraction of the 16S rDNA gene sequence, determination of the closest type strains, and state-of-the-art phylogenomics analysis.
A results page unique to your submission allows you to interactively explore the results and download the parts needed for your work. Using this link you can easily share these results with your collaborators.
The classification or identification of novel strains is done by a dedicated type-based species clustering as opposed to just some arbitrary de-novo clustering at the species or subspecies delimitation threshold. This clustering takes nomenclatural priority and taxonomic conservatism into account. The reported clusters can be visualized on the resulting trees to generate instructive figures.
Many published "genome-based" phylogenetic trees are only based on a fraction of the genes found in the involved genomes. In other cases trees based on a larger, more representative set of genes are presented but without statistical support for the branches; some methods suggested for genome-based taxonomy are even unable to calculate branch support in the first place. In yet other cases authors present clusterings instead of phylogenetic trees. To the contrary, TYGS uses the Genome BLAST Distance Phylogeny (GBDP) method which addresses all of these aspects.
See our portfolio of studies in which GBDP has been applied.